WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00012454 Gene Name  clec-256
Sequence Name  ? Y17D7B.6 Organism  Caenorhabditis elegans
Automated Description  Enriched in pharynx based on RNA-seq studies. Is affected by several genes including rsr-2; lsm-1; and mrps-5 based on tiling array; RNA-seq; and microarray studies. Is affected by Alovudine based on RNA-seq studies. Is predicted to encode a protein with the following domains: C-type lectin fold; C-type lectin-like; C-type lectin-like/link domain superfamily; PAN-like domain; and PAN-3 domain. Biotype  SO:0001217
Genetic Position  V :17.7183 ±0.011507 Length (nt)  ? 950
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00012454

Genomics

1 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:Y17D7B.6.1 Y17D7B.6.1 852   V: 18771690-18772639
 

Other

1 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y17D7B.6 Y17D7B.6 852   V: 18771690-18771971

2 RNAi Result

WormBase ID
WBRNAi00055565
WBRNAi00055566

105 Allele

Public Name
gk963271
gk963489
gk963304
gk963809
gk963637
WBVar02124841
WBVar02120719
gk962724
WBVar02120528
gk963480
WBVar02123778
WBVar02122704
gk964205
WBVar02062855
WBVar02124975
WBVar02122873
WBVar00091258
WBVar01710464
gk792572
gk888738
gk409584
gk395633
WBVar01977677
gk356120
gk747635
gk712866
gk470036
gk713396
gk714394
gk794958

1 Chromosome

WormBase ID Organism Length (nt)
V Caenorhabditis elegans 20924180  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00012454 18771690 18772639 1

2 Data Sets

Name URL
WormBaseAcedbConverter  
C. elegans genomic annotations (GFF3 Gene)  

1 Downstream Intergenic Region

WormBase ID Name Sequence Name Length (nt) Chromosome Location Organism
intergenic_region_chrV_18772640..18773060   421 V: 18772640-18773060 Caenorhabditis elegans

16 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  mRNAs that showed decreased expression in 1 cell mebryo comparing to in oocyte, according to RNAseq analysis. Gaussian error propagation. As cutoff for the up-regulated genes authors used log2 fold change > 1 and P < 0.05 and as cutoff for the down-regulated genes authors used log2 fold change < -1 and P < 0.05. WBPaper00045420:fertilization_downregulated_transcript
  Transcripts expressed in pharynx, according to PAT-Seq analysis using Pmyo-2-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:pharynx_expressed
  Transcripts that showed significantly decreased expression in eat-2(ad1116) comparing to in N2 at 3-days post L4 adult hermaphrodite animals. DESeq2(v1.14.1), fold change > 2, p-value < 0.05 WBPaper00055354:eat-2(ad1116)_downregulated
  Transcripts that showed significantly increased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(-), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage. DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2. WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
  Genes identified as up-regulated at a 5% false discovery rate through RNAseq experiments with three tatn-1(qd182) and three N2 RNA samples. ANOVA with FDR <= 0.05. WBPaper00044656:tatn-1(qd182)_upregulated
  Transcripts that showed significantly increased expression in mrps-5(RNAi) animals comparing to animals injected with empty vector. Differential expression was assessed using a Partial least-squares discriminant analysis (PLS-DA) using mixomics setting a variable of importance (VIP) score of greater than 1 as significant. WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
  Genes that showed significantly increased expression level in rsr-2(RNAi) animals comparing to in gfp(RNAi) control. Fold change > 1.2 or < 0.8. WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
  Transcripts that showed significantly decreased expression in daf-2(e1370) comparing to in N2. Student's t-test, fold change > 2, p-value < 0.05. WBPaper00055386:daf-2(e1370)_downregulated
Bacteria infection: Burkholderia pseudomallei BpR15 Genes that showed increased expression in adult animals after 4 hour exposure to B. pseudomallei R15 vs. exposure to OP50 After array normalization, significance analysis of microarray was performed on data from individual time points (two class unpaired response) to identify genes with small but consistent changes. A false-discovery rate (FDR) of ~1% was used as criteria to consider a gene differentially regulated.Authors chose this particular FDR because it was the lowest FDR that did not significantly reduce the number of estimated true positives. WBPaper00044091:Bpseudomallei_induced_4h
  Transcripts uniquely expressed in pharynx, according to PAT-Seq analysis using Pmyo-2-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:pharynx_enriched
Bacteria infection: Burkholderia pseudomallei BpR15 Genes that showed increased expression in adult animals after 8 hour exposure to B. pseudomallei R15 vs. exposure to OP50 After array normalization, significance analysis of microarray was performed on data from individual time points (two class unpaired response) to identify genes with small but consistent changes. A false-discovery rate (FDR) of ~1% was used as criteria to consider a gene differentially regulated.Authors chose this particular FDR because it was the lowest FDR that did not significantly reduce the number of estimated true positives. WBPaper00044091:Bpseudomallei_induced_8h
Bacteria infection: Burkholderia pseudomallei BpR15 Genes that showed increased expression in adult animals after 12 hour exposure to B. pseudomallei R15 vs. exposure to OP50 After array normalization, significance analysis of microarray was performed on data from individual time points (two class unpaired response) to identify genes with small but consistent changes. A false-discovery rate (FDR) of ~1% was used as criteria to consider a gene differentially regulated.Authors chose this particular FDR because it was the lowest FDR that did not significantly reduce the number of estimated true positives. WBPaper00044091:Bpseudomallei_induced_12h
  Transcripts that showed significantly altered expression after 24 hour exposure to stavudine (FLT) starting at L1 lava stage. DESeq WBPaper00053302:alovudine_72h_regulated
  Genome-wide analysis of developmental and sex-regulated gene expression profile. self-organizing map cgc4489_group_23
Bacteria infection: Burkholderia pseudomallei BpR15 Genes that showed increased expression in adult animals after 2 hour exposure to B. pseudomallei R15 vs. exposure to OP50. After array normalization, significance analysis of microarray was performed on data from individual time points (two class unpaired response) to identify genes with small but consistent changes. A false-discovery rate (FDR) of ~1% was used as criteria to consider a gene differentially regulated.Authors chose this particular FDR because it was the lowest FDR that did not significantly reduce the number of estimated true positives. WBPaper00044091:Bpseudomallei_induced_2h
  Transcripts that showed significantly increased expression in strain GW1125 [lsm-8(-/-)] comparing to WT N2 at L1 larva stage. The EdgeR package v 3.24.0 was used to determine fold changes (Fc) and false discovery rates (FDR) of differential transcript abundances. (FDR < 0.05 AND Fc > 4). WBPaper00059527:lsm-1_upregulated_L1

2 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr1013728 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012  
    Expr1159068 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  

0 GO Annotation

0 Homologues

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00012454 18771690 18772639 1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

Length
950

1 Sequence Ontology Term

Identifier Name Description
gene  

0 Strains

1 Upstream Intergenic Region

WormBase ID Name Sequence Name Length (nt) Chromosome Location Organism
intergenic_region_chrV_18770724..18771689   966 V: 18770724-18771689 Caenorhabditis elegans