WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00001113 Gene Name  dur-1
Sequence Name  ? F25H8.5 Brief Description  The dur-1 ('Dauer UpRegulated') gene encodes proteins (DUR-1A and DUR-1C) that are predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis; expression of at least one dur-1 transcript is upregulated in dauer larvae and other transcripts may be specifically expressed in dauer larvae.
Organism  Caenorhabditis elegans Automated Description  Enriched in several structures, including BAG; PVD; accessory cell; body wall musculature; and germ line based on proteomic; tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; dve-1; and nuo-6 based on proteomic; microarray; and RNA-seq studies. Is affected by twenty-six chemicals including methylmercury hydroxide; 1-methylnicotinamide; and rotenone based on RNA-seq; microarray; and proteomic studies.
Biotype  SO:0001217 Genetic Position  IV :4.44985 ±0.001336
Length (nt)  ? 6293
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00001113

Genomics

22 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:F25H8.5p.1 F25H8.5p.1 1328   IV: 9921938-9928225
Transcript:F25H8.5m.1 F25H8.5m.1 841   IV: 9921938-9928230
Transcript:F25H8.5d.1 F25H8.5d.1 1481   IV: 9921938-9928225
Transcript:F25H8.5m.2 F25H8.5m.2 765   IV: 9921940-9927635
Transcript:F25H8.5a.1 F25H8.5a.1 2455   IV: 9921940-9928223
Transcript:F25H8.5f.1 F25H8.5f.1 903   IV: 9922051-9923745
Transcript:F25H8.5n.1 F25H8.5n.1 498   IV: 9922051-9923745
Transcript:F25H8.5o.1 F25H8.5o.1 804   IV: 9922051-9923745
Transcript:F25H8.5e.1 F25H8.5e.1 1146   IV: 9922051-9924613
Transcript:F25H8.5l.1 F25H8.5l.1 621   IV: 9922051-9924613
Transcript:F25H8.5p.2 F25H8.5p.2 1086   IV: 9922051-9924759
Transcript:F25H8.5s.1 F25H8.5s.1 1299   IV: 9922051-9925603
Transcript:F25H8.5c.1 F25H8.5c.1 2397   IV: 9922051-9928222
Transcript:F25H8.5h.1 F25H8.5h.1 1629   IV: 9922051-9928222
Transcript:F25H8.5i.1 F25H8.5i.1 1632   IV: 9922051-9928222
Transcript:F25H8.5j.1 F25H8.5j.1 1563   IV: 9922051-9928222
Transcript:F25H8.5k.1 F25H8.5k.1 2466   IV: 9922051-9928222
Transcript:F25H8.5q.2 F25H8.5q.2 608   IV: 9922801-9923755
Transcript:F25H8.5q.1 F25H8.5q.1 1063   IV: 9922801-9928225
Transcript:F25H8.5r.1 F25H8.5r.1 357   IV: 9923201-9923745
Transcript:F25H8.5b.1 F25H8.5b.1 1352   IV: 9924886-9928223
Transcript:F25H8.5g.1 F25H8.5g.1 1179   IV: 9925127-9928222
 

Other

19 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F25H8.5a F25H8.5a 2343   IV: 9922051-9922097
CDS:F25H8.5n F25H8.5n 498   IV: 9922051-9922097
CDS:F25H8.5l F25H8.5l 621   IV: 9922051-9922097
CDS:F25H8.5s F25H8.5s 1299   IV: 9922051-9922097
CDS:F25H8.5i F25H8.5i 1632   IV: 9922051-9922097
CDS:F25H8.5k F25H8.5k 2466   IV: 9922051-9922097
CDS:F25H8.5q F25H8.5q 468   IV: 9922931-9923022
CDS:F25H8.5r F25H8.5r 357   IV: 9923201-9923313
CDS:F25H8.5b F25H8.5b 1110   IV: 9925127-9925152
CDS:F25H8.5g F25H8.5g 1179   IV: 9925127-9925152
CDS:F25H8.5c F25H8.5c 2397   IV: 9922051-9922097
CDS:F25H8.5d F25H8.5d 1365   IV: 9922051-9922097
CDS:F25H8.5e F25H8.5e 1146   IV: 9922051-9922097
CDS:F25H8.5f F25H8.5f 903   IV: 9922051-9922097
CDS:F25H8.5h F25H8.5h 1629   IV: 9922051-9922097
CDS:F25H8.5j F25H8.5j 1563   IV: 9922051-9922097
CDS:F25H8.5m F25H8.5m 501   IV: 9922051-9922097
CDS:F25H8.5o F25H8.5o 804   IV: 9922051-9922097
CDS:F25H8.5p F25H8.5p 750   IV: 9922051-9922097

6 RNAi Result

WormBase ID
WBRNAi00000403
WBRNAi00000850
WBRNAi00045557
WBRNAi00013892
WBRNAi00031404
WBRNAi00023441

88 Allele

Public Name
gk964278
gk964078
gk964500
gk962765
WBVar02069838
otn1882
gk539563
gk859562
gk777145
gk744812
WBVar01856449
WBVar01856448
WBVar01856447
WBVar01856446
WBVar01856450
WBVar02058558
cxTi710
gk310014
WBVar01668801
otn3235
gk834480
gk465706
gk691903
gk656236
gk448371
gk672559
gk807083
gk436240
gk597463
gk379965

1 Chromosome

WormBase ID Organism Length (nt)
IV Caenorhabditis elegans 17493829  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00001113 9921938 9928230 -1

3 Data Sets

Name URL
WormBaseAcedbConverter  
C. elegans genomic annotations (GFF3 Gene)  
Panther orthologue and paralogue predictions  

0 Downstream Intergenic Region

306 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Genes with expression altered >= 3-fold in dpy-10(e128) mutants. Data across the wild type series was analyzed using the Significance analysis of Microarrays (SAM) algorithm (to calculate the False Discovery Rate (FDR)). WBPaper00035873:dpy-10_regulated
  Transcripts expressed in neuronal cells, by analyzingfluorescence-activated cell sorted (FACS) neurons. DESeq. False discovry rate (FDR) < 0.1. WBPaper00048988:neuron_expressed
  Transcripts that showed significantly increased expression glp-1(e2141); TU3401 animals comparing to in TU3401 animals. Fold change > 2, FDR < 0.01. WBPaper00065993:glp-1(e2141)_upregulated
adult vs dauer larva Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C. N.A. WBPaper00050488:adult_vs_dauer_regulated_N2_20C
  TGF- Dauer pathway adult transcriptional targets. Results obtained by comparing the microarray results of the dauer-constitutive mutants daf-7(e1372), daf-7(m62), and daf-1(m40) with dauer-defective mutants daf-3(mgDf90), daf-5(e1386), and daf-7(e1372);daf-3(mgDf90) double mutants at the permissive temperature, 20C, on the first day of adulthood. SAM WBPaper00031040:TGF-beta_adult_upregulated
Osmotic stress Transcripts that showed significantly altered expression with 500 mM salt (NaCl) vs 100 mM salt when no food was present DESeq(version 1.10.1), FDR < 0.05. WBPaper00050726:OsmoticStress_regulated_NoFood
  Genes that showed increased expression in wdr-5(ok1417) comparing with in N2. Statistical analysis for misexpression was performed using a moderated t test from the package limma. All genes with a false discovery rate (FDR) of <= 5% (p <= 0.05) were selected as differentially regulated. WBPaper00045861:wdr-5(ok1417)_upregulated
Bacteria: E.faecalis strain OG1RF Transcripts that showed significantly increased expression after infection by E. faecalis OG1RF. Ballgown was used to calculate differential expression of genes using FPKM data and to generate tables with fold change and P values. Genes were shortlisted with a cutoff of 2-fold change and P values of less than 0.05. WBPaper00059754:E.faecalis_OG1RF_upregulated
  Transcripts that showed significantly decreased expression in eat-2(ad465) comparing to in N2. DESeq2 1.30.1, fold change > 2, FDR < 0.05. WBPaper00066890:eat-2(ad465)_downregulated
  Transcripts that showed significantly increased expression in eft-2(RNAi) animals at N2 background. DESeq2, fold change > 2 and p-value < 0.01. WBPaper00067953:eft-2(RNAi)_upregulated_N2
  Transcripts that showed significantly decreased expression in pha-4(RNAi) comparing to in N2. DESeq2 1.30.1, fold change > 2, FDR < 0.05. WBPaper00066890:pha-4(RNAi)_downregulated
  Transcripts that showed significantly increased expression in eif-2alpha(RNAi) animals at N2 background. DESeq2, fold change > 2 and p-value < 0.01. WBPaper00067953:eif-2alpha(RNAi)_upregulated_N2
  Transcripts that showed significantly increased expression in eif-2alpha(RNAi) animals at zip-2(tm4248) background. DESeq2, fold change > 2 and p-value < 0.01. WBPaper00067953:eif-2alpha(RNAi)_upregulated_zip-2(tm4248)
  Transcripts expressed in the epithelial tissues surrounding the pharynx that includes the arcade and intestinal valve (AIV) cells, according to PAT-Seq analysis using Pbath-15-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:arcade_intestinal-valve_expressed
  Transcripts expressed in body muscle, according to PAT-Seq analysis using Pmyo-3-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:body-muscle_expressed
  Transcripts expressed in GABAergic neuron, according to PAT-Seq analysis using Punc-47-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:GABAergic-neuron_expressed
  Proteins interacting with NHR-49-GFP according to co-IP and LC-MS. N.A. WBPaper00064071:NHR-49_interacting
  Transcripts expressed in hypodermis, according to PAT-Seq analysis using Pdpy-7-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:hypodermis_expressed
  Transcripts that showed significantly decreased expression in atfs-1(cmh15) (null allele) animals comparing to in N2 animals at L4 larva stage. edgeR, fold change > 2, FDR < 0.05 WBPaper00060909:atfs-1(cmh15)_downregulated
  Transcripts expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:intestine_expressed
  Transcripts expressed in NMDA neuron, according to PAT-Seq analysis using Pnmr-1-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:NMDA-neuron_expressed
  Genes with expression level regulated by genotype (N2 vs CB4856) and age at L3 larva and Late reproduction stage (96 hours at 24 centigrade). For model 2, authors used 100 permutations to estimate the FDR threshold. Per permutation, genotypes and ages were independently randomly distributed, keeping the among-gene structure intact. Then for each spot (23,232) on the array, model 2 was tested. The obtained P-values were used to estimate a threshold for each of the explanatory factors. Authors also used a genome-wide threshold of -log10 P-value = 2, which resembles an FDR of 0.072 and 0.060 for marker and the interaction age-marker for the developing worms and FDR of 0.050 and 0.065 for marker and age-marker for the aging worms. For the physiological age effect, authors used a log10 P-value = 8 in developing worms (0.012 FDR) and -log10 P-value = 6 (0.032 FDR). WBPaper00040858:eQTL_age_regulated_developing
  Transcripts expressed in seam cells, according to PAT-Seq analysis using Pgrd-10-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:seam_expressed
  Transcripts that showed significantly decreased expression at 11-days-post L4 adult N2 hermaphrodites comparing to 1-day-post L4 adult N2 hermaphrodites. DESeq2, fold change > 2, FDR < 0.05 WBPaper00065835:Day11_vs_Day1_downregulated
  Genes with expression level regulated by genotype (N2 vs CB4856) at L3 larva and Late reproduction stage (96 hours at 24 centigrade). For model 2, authors used 100 permutations to estimate the FDR threshold. Per permutation, genotypes and ages were independently randomly distributed, keeping the among-gene structure intact. Then for each spot (23,232) on the array, model 2 was tested. The obtained P-values were used to estimate a threshold for each of the explanatory factors. Authors also used a genome-wide threshold of -log10 P-value = 2, which resembles an FDR of 0.072 and 0.060 for marker and the interaction age-marker for the developing worms and FDR of 0.050 and 0.065 for marker and age-marker for the aging worms. For the physiological age effect, authors used a log10 P-value = 8 in developing worms (0.012 FDR) and -log10 P-value = 6 (0.032 FDR). WBPaper00040858:eQTL_regulated_developing
  Transcripts that showed significantly decreased expression in day 3 adult hermaphrodite comparing to in L4 larva daf-16(mu86);glp-1(e2141) animals. Fold change > 2, FDR < 0.05 WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
  Transcripts that showed significantly decreased expression in day 3 adult hermaphrodite comparing to in L4 larva glp-1(e2141) animals. Fold change > 2, FDR < 0.05 WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
Bacteria: Pseudomonas donghuensis HYS Transcripts that showed significantly increased expression after 24 hours of infection by Pseudomonas donghuensis HYS with deletion of ferric uptake regulator (FUR), comparing to control animals exposed to OP50. DESeq2, fold change > 2, FDR < 0.05. WBPaper00068216:FUR_vs_OP50_upregulated
Bacteria infection: Bacillus thuringiensis Transcripts that showed significantly increased expression in N2 animals infected by bacteria BMB171/Cry5Ba, an acrystalliferous Bt mutant BMB171 transformed with toxin gene cry5Ba on the shuttle vector pHT304, comparing to N2 animals infected by BMB171/pHT304. N.A. WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
  Transcripts that showed significantly increased expression in sin-3(tm1276) comparing to in N2. DESeq2, fold change > 2, p-value < 0.01. WBPaper00061203:sin-3(tm1276)_upregulated

5 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr1030710 Tiling arrays expression graphs  
    Expr2011117 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr2029353 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr1149472 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  
    Expr1017740 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012  

0 GO Annotation

2 Homologues

Type
orthologue
orthologue

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00001113 9921938 9928230 -1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

Length
6293

1 Sequence Ontology Term

Identifier Name Description
gene  

1 Strains

WormBase ID
WBStrain00035979

1 Upstream Intergenic Region

WormBase ID Name Sequence Name Length (nt) Chromosome Location Organism
intergenic_region_chrIV_9928231..9930895   2665 IV: 9928231-9930895 Caenorhabditis elegans