Ppa-lin-39 encodes a homeodomain protein homologous to the Deformed and Sex combs reduced family of homeodomain proteins; Ppa-lin-39 is required for specification of mid-body region cell fates, including those of the VC neurons and the vulval precursor cells (VPCs), during postembryonic development; P(5-8).p in the central body region die of programmed cell death in Ppa-lin-39 mutants and thereby, adopt the fate of the anterior and posterior lineage homologs P(1-4,9-11).p; Cel-lin-39 and Ppa-lin-39 provide positional information to the VPCs in a similar manner; Ppa-lin-39, in contrast to Cel-lin-39, is not required as a transcription factor in response to the inductive signal for vulva formation.
Organism
Pristionchus pacificus
Automated Description
Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is an ortholog of C. elegans lin-39. In C. elegans, lin-39 is involved in several processes, including positive regulation of DNA-templated transcription; positive regulation of developmental process; and regulation of cell division.