WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00012075 Gene Name  T27A8.3
Sequence Name  ? T27A8.3 Organism  Caenorhabditis elegans
Automated Description  Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Is an ortholog of human METAP2 (methionyl aminopeptidase 2). Biotype  SO:0001217
Genetic Position  :± Length (nt)  ? 606
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00012075

Genomics

1 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:T27A8.3.1 T27A8.3.1 549   X: 16062685-16063290
 

Other

1 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:T27A8.3 T27A8.3 549   X: 16062685-16063135

7 RNAi Result

WormBase ID
WBRNAi00048090
WBRNAi00054268
WBRNAi00003746
WBRNAi00019303
WBRNAi00032677
WBRNAi00089086
WBRNAi00089170

18 Allele

Public Name
gk964260
gk962707
gk963810
gk963581
gk963633
gk962525
tm11440
gk962524
gk963443
tm11395
gk837865
gk726587
gk547229
gk304878
otn17329
WBVar01473184
WBVar01528924
gk960702

1 Chromosome

WormBase ID Organism Length (nt)
X Caenorhabditis elegans 17718942  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00012075 16062685 16063290 1

4 Data Sets

Name URL
WormBaseAcedbConverter  
GO Annotation data set  
C. elegans genomic annotations (GFF3 Gene)  
Panther orthologue and paralogue predictions  

0 Downstream Intergenic Region

15 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Significantly downregulated genes from cyc-1(RNAi) microarrays using SAM algorithm with an FDR < 0.1 from adult-only chips. SAM algorithm with an FDR < 0.1. WBPaper00033065:cyc-1(RNAi)_downregulated
Bacteria infection: Photorhabdus luminescens Genes with increased expression after 24 hours of infection by P.lumniescens Fold changes shown are pathogen vs OP50. For RNA-seq and tiling arrays, log2 fold changes between gene expression values of infected versus uninfected nematodes were calculated. For log2 fold changes > 0.00001 the values > 81.25th percentile were defined as up-regulated and for log2 fold changes < -0.00001 the values < 18.75th percentile were defined as down-regulated. WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
  Proteins expressed in intestine cytoplasm, according to tissue specific APX enzyme expression using spp-5 promoter driven NES(cytoplasm)-GFP-APX, followed with mass spectrometry. Fold change > 2. WBPaper00051245:intestine_cytoplasm_expressed
  Transcripts that interact with 3xFLAG-DLC-1 as identified by immunoprecipitation followed by RNA sequencing. DESeq2, fold change > 2,, p-value < 0.01 WBPaper00055334:DLC-1_interacting
  Transcripts that showed significantly decreased expression in ogt-1(ok1474) neuronal cells isolated by FACs comparing to in FACs isolated neuronal cells from wild type. DESeq2, fold change > 2, FDR < 0.05. WBPaper00066485:ogt-1(ok1474)_downregulated_neuron
  Proteins expressed in body wall muscle cytoplasm, according to tissue specific APX enzyme expression using myo-3 promoter driven NES(cytoplasm)-GFP-APX, followed with mass spectrometry. Fold change > 2. WBPaper00051245:body-wall-muscle_cytoplasm_expressed
  Proteins specifically expressed in cytoplasm, according to tissue specific APX enzyme expression driven NES(cytoplasm)-GFP-APX, followed with mass spectrometry. Fold change > 2. WBPaper00051245:cytoplasm_specific
  Proteins expressed in epidermis cytoplasm, according to tissue specific APX enzyme expression using dpy-7 promoter driven NES(cytoplasm)-GFP-APX, followed with mass spectrometry. Fold change > 2. WBPaper00051245:epidermis_cytoplasm_expressed
  Proteins expressed in pharyngeal muscle cytoplasm, according to tissue specific APX enzyme expression using myo-2 promoter driven NES(cytoplasm)-GFP-APX, followed with mass spectrometry. Fold change > 2. WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
  Genes that showed significantly decreased expression after exposure to 1mg/L MWCNTs from L1 larva to young adult. Transcripts with false discovery rate-corrected p-values < 0.05 and fold change > 2 were defined as differentially expressed. WBPaper00049377:MWCNT_downregulated
  Genes that showed significantly increased expression level in rsr-2(RNAi) animals comparing to in gfp(RNAi) control. Fold change > 1.2 or < 0.8. WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
  Transcripts that showed significantly decreased expression in spn-4(tm291) comparing to in N2 at early embryo when there were only 3 -5 eggs in the adult. RPKM fold change > 2. WBPaper00058598:spn-4(tm291)_downregulated
  Transcripts that showed significantly decreased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(+), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage. DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2. WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
Bacteria: C.neoformans strain H99 Transcripts that showed significantly increased expression after infection by C. neoformans H99. Ballgown was used to calculate differential expression of genes using FPKM data and to generate tables with fold change and P values. Genes were shortlisted with a cutoff of 2-fold change and P values of less than 0.05. WBPaper00059754:C.neoformans_H99_upregulated
  Neuronal proteins that showed significantly decreased expression in day 12 adult comparing to in day 1 adult through in vivo TurboIDlabeling proteomic profiling. DESeq2, log2FC > 1, FDR < 0.05 WBPaper00064789:Day12_vs_Day1_downregulated_neuron

1 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr1157816 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  

7 GO Annotation

Annotation Extension Qualifier
  enables
  enables
  enables
  located_in
  involved_in
  enables
  enables

8 Homologues

Type
orthologue
orthologue
orthologue
orthologue
orthologue
orthologue
orthologue
orthologue

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00012075 16062685 16063290 1

7 Ontology Annotations

Annotation Extension Qualifier
  enables
  enables
  enables
  located_in
  involved_in
  enables
  enables

0 Regulates Expr Cluster

1 Sequence

Length
606

1 Sequence Ontology Term

Identifier Name Description
gene  

0 Strains

0 Upstream Intergenic Region