WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00108414 Genotype  IFB-1A::GFP (juIs176)
Phenotype Remark  Analysis of smo-1(RNAi) viable embryos revealed an abnormal pattern of IFB-1 expression (Figures 4I-4P). As soon as GFP fluorescence could be detected at the comma stage and later, at 1.5-fold stage, IFB-1 was localized to abnormal thick and short filamentous structures in all regions of the epidermis (detected in 34/38 embryos analyzed) while cytoplasmic staining was very weak or undetectable (32/38 embryos). Authors suggest that SUMO is required to keep IFB-1 in a soluble fraction that serves as storage for free subunits necessary for filament formation during elongation. Remark  Authors used the feeding-RNAi approach to deplete SUMO and selected for embryos that had enough SUMO to perform embryonic cell divisions until the comma stage (early elongation).
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00004888 smo-1 K12C11.2 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:K12C11.2 K12C11.2 276   I: 1340703-1340768

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000679 transgene subcellular localization variant Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00035491

0 Strain