| Primary Identifier | Expr1196 | Remark | A subcellular distribution analogous to the one reported here was observed in C. elegans embryos using polyclonal antibodies raised against purified dynein heavy chain protein. |
| Subcellular Localization | Cytoplasmic dynein was present in a punctate manner throughout the cytoplasm at all stages of the cell cycle. A stronger signal was detected at the periphery of pronuclei in one cell stage embryos and of nuclei in later stage embryos. Cytoplasmic dynein was present at the cell cortex; especially apparent at boundaries between cells, for instance, between the AB and P1 blastomeres of the two cell stage embryo. The distribution of cytoplasmic dynein changed as cells progressed through mitosis. During prometaphase, cytoplasmic dynein accumulated along both sides of prometaphase chromosomes. During early anaphase, strong spindle signal was still detected, both between segregating chromosomes and spindle poles, as well as centrally, between the two sets of chromosomes. A similar staining pattern persisted throughout anaphase. At telophase, cytoplasmic dynein was enriched in two areas of the cytoplasm adjacent to the spindle poles. A strong signal was detected at the periphery of reforming nuclei. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000962 | dhc-1 | T21E12.4 | Caenorhabditis elegans |
| Remark | Definition | Other Name | Public Name | Primary Identifier |
|---|---|---|---|---|
| The C. elegans life stage spanning 0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage until the start of gastrulation. | blastula embryo Ce | WBls:0000005 |
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