WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Primary Identifier  Expr13458 Subcellular Localization  Epifluorescence microscopy revealed that mCherry::DHC-1 and eGFP::DHC-1 are expressed in all somatic tissues and in the germline. After imaging early embryos by spinning-disk confocal fluorescence microscopy (SDCM), DHC-1 was detected in the cytoplasm during all stages of the cell cycle and localized specifically to the nuclear envelope, centrosomes, kinetochores, kinetochore MTs, central spindle, astral MTs, and the cell cortex during mitosis. This localization pattern is in accordance with previous immunohistochemistry and overexpression studies (Schmidt et al., 2005; Nguyen-Ngoc et al., 2007; Gassmann et al., 2008; Kimura and Kimura, 2011). In addition, we noticed comet like accumulations of dynein radiating from the centrosomes to the cell periphery in a pattern that appeared to follow the mitotic astral MT network.Endogenous dynein complex tracks MT plus ends. This was observed in one cell embryos and in later stages of C. elegans embryos (4-cell embryos).
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2 Anatomy Terms

Definition Name Synonym Primary Identifier
Nucleated cell which has a diploid set of chromosomes. somatic cell FMA:72300 WBbt:0008378
a cell, of either sex, directly concerned in the production of a new organism. germ cell   WBbt:0006796

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00000962 dhc-1 T21E12.4 Caenorhabditis elegans

2 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  Also called zygote. -50min till 0min of first cleavage at 20 Centigrade. Contains 1 cell. 1-cell embryo Ce WBls:0000006
  The C. elegans life stage spanning 20-40min after first cleavage at 20 Centigrade. Contains 4 cells. 4-cell embryo Ce WBls:0000008