WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  Immunoreactive PLP-1 localizes to the nuclei of all blastomeres beginning by the two-cell stage of embryogenesis, implying that PLP-1 is a maternally encoded transcription factor. It is also present in the germline-specific P granules of early embryos. Primary Identifier  Expr8706
Remark  Picture: Fig. 5. The same pattern was seen with two separate antibodies raised against distinct PLP-1 peptides, and both nuclear and P granule expression was largely eliminated in plp-1 (RNAi) embryos, confirming their specificity. Subcellular Localization  PLP-1 is transiently asymmetrically localized during telophase of the dividing EMS cell (observed in 12 embryos at the correct stage), with higher levels of the protein in the chromatin of the future E cell nucleus and low or undetectable levels in that of MS. A similar transient asymmetry in PLP-1 levels was observed at many divisions throughout early development, starting at cleavage of the zygote, with higher levels seen in the cytoplasm and forming nucleus of the posterior daughter, P1 (observed in 5 embryos). The anteroposterior asymmetry in PLP-1 was also observed in the AB lineage during the division of the AB granddaughters (observed in 7 embryos): for example, PLP-1 is higher in the chromatin of the posterior daughter ABalp than that of its anterior sister ABala. In all cases, the asymmetry was observed only during telophase and at the time that nuclei were reassembling after cell division; the staining was symmetric at all other times. PLP-1 was always seen at higher levels in the forming nuclei of the posterior daughters.
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55 Anatomy Terms

Definition Name Synonym Primary Identifier
embryonic cell MSa   WBbt:0006086
embryonic cell MSp   WBbt:0005912
Embryonic founder cell MS lineage name: P0.paa WBbt:0004458
embryonic cell ABarp   WBbt:0006653
embryonic cell ABprp   WBbt:0006451
embryonic cell Ep   WBbt:0006612
embryonic cell ABplp   WBbt:0006279
embryonic cell ABalp   WBbt:0005865
Embryonic founder cell E lineage name: P0.pap WBbt:0004804
Single cell zygote P0 lineage name: Z WBbt:0004422
embryonic cell MSpa   WBbt:0006142
embryonic founder cell Psub3 lineage name: P0.ppp WBbt:0006875
embryonic cell Cpa   WBbt:0006281
embryonic founder cell Psub1 lineage name: P0.p WBbt:0006874
embryonic founder cell Psub2 lineage name: P0.pp WBbt:0006873
Embryonic founder cell D lineage name: P0.pppa WBbt:0004873
embryonic cell MSpp   WBbt:0006255
Embryonic founder cell of germ line Psub4 lineage name: P0.pppp WBbt:0004421
embryonic cell EMS   WBbt:0006876
embryonic cell ABplap   WBbt:0006096
embryonic cell ABalap   WBbt:0006101
embryonic cell ABala   WBbt:0006707
embryonic cell ABarap   WBbt:0005903
embryonic cell ABal   WBbt:0006110
embryonic cell ABprpa   WBbt:0005915
embryonic cell Cp   WBbt:0006117
embryonic cell ABa   WBbt:0005906
embryonic cell ABplpa   WBbt:0005950
embryonic cell ABpla   WBbt:0006341
embryonic cell ABprap   WBbt:0005922

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00004046 plp-1 F45E4.2 Caenorhabditis elegans

0 Life Stages