WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00224945 Gene Name  Bma-mtm-5
Sequence Name  ? Bm4684 Organism  Brugia malayi
Automated Description  Enriched in reproductive tract based on proteomic studies. Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: C1-like domain superfamily; Myotubularin family; PH-like domain superfamily; SBF1/SBF2 domain; Protein kinase C-like, phorbol ester/diacylglycerol-binding domain; dDENN domain; Protein-tyrosine phosphatase-like; Myotubularin-like, phosphatase domain; Myotubularin-like phosphatase domain; DENN (AEX-3) domain; Pleckstrin homology domain; PH domain; DENN domain, C-terminal lobe; cDENN domain; Myotubularin protein; GRAM domain; and uDENN domain. Is an ortholog of C. elegans mtm-5. Biotype  SO:0001217
Genetic Position  :±
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1 Organism

Name Taxon Id
Brugia malayi 6279

0 Synonyms

Genomics

3 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:Bm4684a.1 Bm4684a.1   [unknown]
Transcript:Bm4684b.2 Bm4684b.2   [unknown]
Transcript:Bm4684b.1 Bm4684b.1   [unknown]
 

Other

2 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Bm4684b Bm4684b   [unknown]
CDS:Bm4684a Bm4684a   [unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

Name URL
WormBaseAcedbConverter  

0 Downstream Intergenic Region

6 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_F120
  Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_F120_vs_F30
  Proteins that are enriched in productive tract of adult female Brugia malayi. Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. WBPaper00048706:productive-tract_enriched
  Transcripts that showed significantly decreased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M30_vs_L4
  Transcripts that showed significantly increased expression in female B. malayi 30 days after infecting gerbils, comparing to L4 female B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F30_vs_L4
  Transcripts that showed significantly decreased expression after 48 hours of 300nM ivermectin exposure. Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). WBPaper00049974:ivermectin_300nM_48h_downregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term

Identifier Name Description
gene  

0 Strains

0 Upstream Intergenic Region