WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00225694 Gene Name  Bma-der-2
Sequence Name  ? Bm5433 Organism  Brugia malayi
Automated Description  Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Der1-like family; Derlin; and Rhomboid-like superfamily. Is an ortholog of C. elegans der-2. In C. elegans, der-2 is involved in IRE1-mediated unfolded protein response. Biotype  SO:0001217
Genetic Position  :±
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1 Organism

Name Taxon Id
Brugia malayi 6279

0 Synonyms

Genomics

1 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:Bm5433.1 Bm5433.1   [unknown]
 

Other

1 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Bm5433 Bm5433   [unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

Name URL
WormBaseAcedbConverter  

0 Downstream Intergenic Region

4 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly lower expression in L3 larva comparing to in adult. edgeR v3.28. FDR < 0.05, fold change > 2. WBPaper00061765:L3_vs_Adult_Downregulated
  Transcripts that showed significantly decreased expression after 48 hours of 100nM ivermectin exposure. Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). WBPaper00049974:ivermectin_100nM_48h_downregulated
  Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F120_vs_F30
  Transcripts that showed significantly lower expression in L4 larva comparing to in adult. edgeR v3.28. FDR < 0.05, fold change > 2. WBPaper00061765:L4_vs_Adult_Downregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term

Identifier Name Description
gene  

0 Strains

0 Upstream Intergenic Region