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Transcripts that showed significantly higher expression in L3 larva comparing to in adult. |
edgeR v3.28. FDR < 0.05, fold change > 2. |
WBPaper00061765:L3_vs_Adult_Upregulated
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Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_M120_vs_F120
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Transcripts that showed significantly higher expression in L4 larva comparing to in adult. |
edgeR v3.28. FDR < 0.05, fold change > 2. |
WBPaper00061765:L4_vs_Adult_Upregulated
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Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_F120_vs_F30
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Proteins that are enriched in productive tract of adult female Brugia malayi. |
Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. |
WBPaper00048706:productive-tract_enriched
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Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_M120_vs_M30
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Proteins secreted by B.malayi at L3 larva stage, according to LC-MS-MS. |
N.A. |
WBPaper00050454:Secretome_protein
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Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:upregulated_M30_vs_L4
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Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone. |
An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed. |
WBPaper00049261:20-hydroxyecdysone_upregulated_protein
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Time-course transcript abundance profiles. P116, k-means clusters of Brugia malayi during development in Aedes aegypti LVP between day 1 and 8 post infection; H114, k-means clusters of Ae. aegypti LVP infected with B. malayi between day 0 and 8 post infection; and HR14, host response profile comparing infected vs. uninfected A. aegypti LVP. |
Non-flat profiles (p < 0.01 and maximum fold-difference among time points > 2) were grouped into common temporal patterns using k-means clustering. |
WBPaper00045439:BM_Cluster_P6
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Transcripts that showed significantly decreased expression in female B. malayi 30 days after infecting gerbils, comparing to L4 female B. malayi animals. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_F30_vs_L4
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Transcripts that showed significantly increased expression after 48 hours of 100nM ivermectin exposure. |
Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). |
WBPaper00049974:ivermectin_100nM_48h_upregulated
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