WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00220898 Gene Name  Bma-vps-37
Sequence Name  ? Bm637 Organism  Brugia malayi
Automated Description  Enriched in reproductive tract based on proteomic studies. Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Helix hairpin bin domain superfamily; Modifier of rudimentary, Modr; Modifier of rudimentary (Mod(r)) protein; and ESCRT assembly domain. Is an ortholog of C. elegans vps-37. In C. elegans, vps-37 is involved in receptor catabolic process. Biotype  SO:0001217
Genetic Position  :±
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1 Organism

Name Taxon Id
Brugia malayi 6279

0 Synonyms

Genomics

2 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:Bm637b.1 Bm637b.1   [unknown]
Transcript:Bm637a.1 Bm637a.1   [unknown]
 

Other

2 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Bm637a Bm637a   [unknown]
CDS:Bm637b Bm637b   [unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

Name URL
WormBaseAcedbConverter  

0 Downstream Intergenic Region

7 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly higher expression in L3 larva comparing to in adult. edgeR v3.28. FDR < 0.05, fold change > 2. WBPaper00061765:L3_vs_Adult_Upregulated
  Transcripts that showed significantly higher expression in L4 larva comparing to in adult. edgeR v3.28. FDR < 0.05, fold change > 2. WBPaper00061765:L4_vs_Adult_Upregulated
  Proteins that are enriched in productive tract of adult female Brugia malayi. Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. WBPaper00048706:productive-tract_enriched
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_M30
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_M42
  Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M120_vs_F120
  Transcripts that showed significantly increased expression after 48 hours of 300nM ivermectin exposure. Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). WBPaper00049974:ivermectin_300nM_48h_upregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term

Identifier Name Description
gene  

0 Strains

0 Upstream Intergenic Region