clk-3 is required for normal behavioral rhythms and normally shortlifepsan; despite its behavioral phenotype, clk-3 is thought to actearly in development, since the clock phenotype of clk-3 mutants ismaternal; clk-3 phenotypes include slow and variable development fromembryo to adult, slow cell cycles, abnormally long lifespan, and slowand irregular rhythmic behaviors (swimming, pharyngeal pumping, anddefecation); clk-3 mutations can be strongly rescued either maternallyor zygotically; double mutants of clk-3 with phenotypically similargenes (clk-1, clk-2, or gro-1) generally develop and age more slowlythan clk-3 mutants; despite their slow development and aging, clk-3animals have a normal metabolic rate.
Organism
Caenorhabditis elegans
Automated Description
Acts upstream of or within determination of adult lifespan.