WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00110038 Genotype  ccIs4251 [pSAK4 (myo-3 promoter driving mitochondrially targeted GFP); pSAK2 (myo-3 promoter driving a nuclear-targeted GFP::LacZ fusion); and a dpy-20 subclone]
Phenotype Remark  "Next, we performed RNAi against a set of 10 knockdowns previously shown to produce embryonic lethality [icd-1 (inhibitor of celldeath), snr-6 (small nuclear ribonucleoprotein), npp-20 (nuclear pore complex protein), vha-9 (vaculolar ATPase), nap-1 (nucleosome assembly protein), ufd-1 (ubiquitin fusion degradation), fnta-1 (farnesyltransferase), pbs-2 (proteasome b-subunit), cyb-2.1 (cyclin B), and crn-1 (cell death related nuclease)]. In each case, we found embryonic lethality as expected. When these genes were knocked down in fully developed adults, we further found both increased protein degradation and loss of mitochondrial reticular structure but no defects in the sarcomere structure." Remark  cyb-2.1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

2 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00000866 cyb-2.1 Y43E12A.1 Caenorhabditis elegans
WBGene00000867 cyb-2.2 H31G24.4 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:H31G24.4 H31G24.4 1020   I: 4114878-4115281
CDS:Y43E12A.1 Y43E12A.1 954   IV: 10986002-10986339

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001577 mitochondria alignment variant Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00046120

0 Strain