WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00078098 Genotype  baInl3; Punc-54::alpha-syn::gfp, Punc-54::tor-2, rol-6(su1006)
Phenotype Remark  The misfolding and aggregation of alpha-syn::GFP is enhanced following RNAi targeting W08D2.5 in this sensitized background. Remark  The strain used overexpresses both alpha-Synuclein and TOR-2. Overexpression of alpha-syn (Punc-54::a-syn::GFP) results in misfolding and aggregation of alpha-syn in body wall muscle cells at the young adult stage. Co-overexpression of TOR-2 (Punc-54::tor-2), a protein with chaperone activity, attenuates the misfolding of the alpha-syn::GFP protein.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00012341 catp-6 W08D2.5 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:W08D2.5a W08D2.5a 3804   IV: 9817710-9817842
CDS:W08D2.5c W08D2.5c 3624   IV: 9817710-9817842

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001405 protein aggregation variant Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00032527

0 Strain