WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00110239 Genotype  zcIs13 [hsp-6p::GFP]; rmIs101 [rgef-1p::Q40::YFP]
Phenotype Remark  "We predicted that the cell-non-autonomous induction of mitochondrial chaperones observed with neuronal polyQ40 expression requires one or more essential UPRmt factors. To test this hypothesis, we applied RNAi against ubl-5, dve-1, atfs-1, and clpp-1, and cco-1 to neuronal polyQ40 worms expressing hsp-6p::GFP. RNAi against dve-1, atfs-1, and clpp-1 blocked the induction of the hsp-6p::GFP reporter in peripheral tissues, while cco-1 RNAi showed robust induction (Figures 2A and 2B)." Remark  (Figure 2A, 2B) clpp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

6 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00007022 mdt-22 ZK970.3 Caenorhabditis elegans
WBGene00014172 clpp-1 ZK970.2 Caenorhabditis elegans
WBGene00014638 ZK970.t4 ZK970.t4 Caenorhabditis elegans
WBGene00014635 ZK970.t1 ZK970.t1 Caenorhabditis elegans
WBGene00014637 ZK970.t3 ZK970.t3 Caenorhabditis elegans
WBGene00014636 ZK970.t2 ZK970.t2 Caenorhabditis elegans

4 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:ZK970.2d ZK970.2d 666   II: 10300824-10300934
CDS:ZK970.2b ZK970.2b 354   II: 10300824-10300934
CDS:ZK970.3 ZK970.3 474   II: 10301247-10301321
CDS:ZK970.2a ZK970.2a 621   II: 10300824-10300934

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001278 transgene expression reduced Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00050142

0 Strain