WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00108046 Genotype  daf-2(e1370)
Phenotype Remark  "We therefore investigated whether dosage modulation of pdp-1 would affect additional outputs of the pathway. We first tested the role of PDP-1 in regulating lifespan (Figure 2 and Figure S4). The lifespan of wild-type worms was not affected by pdp-1 RNAi and slightly reduced by a mutation in pdp-1 (Figure 2A and 2D). In contrast, the mean and maximal lifespan of long-lived daf-2(e1370) and age-1(hx546) mutants was significantly reduced by pdp-1 RNAi (Figure 2B and 2C)." Remark  (Figure 2B,S4B) pdp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

2 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00022832 pdp-1 ZK973.3 Caenorhabditis elegans
WBGene00022834 ZK973.8 ZK973.8 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:ZK973.3 ZK973.3 1356   I: 4368106-4368182

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001171 shortened life span The duration of viability in the adult phase of the life-cycle is less than that of control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00038374

0 Strain