WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00114744 Genotype  drIs28[myo-3p::GR50-GFP]
Phenotype Remark  "Two independent paralysis assays showed that animals on dss-1(RNAi) exhibited reduced paralysis compared to the negative control EV(RNAi) (Figure 1B). In addition to these phenotypes, the other toxic DPR made via the C9orf72 repeat expansion mutation, (GR)50, showed similar results (Figure 1C). This decrease in C. elegans age-dependent paralysis following dss-1(RNAi) shows that dss-1 normally functions to facilitate (PR)50 and (GR)50 induced age-dependent paralysis... Two independent VSA [video speed analysis] trials showed increased motility in (PR)50 expressing animals on dss-1(RNAi) compared to EV(RNAi) (Figure 1D, F). (GR)50, showed similar results (Figure 1E, G)." Remark  dss-1 (WBGene00022492) RNAi, ORFeome clone
Paste the following link
Lists
This RNAi isn't in any lists. Upload a list.

1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00022492 dss-1 Y119D3B.15 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y119D3B.15 Y119D3B.15 249   III: 1194668-1194805

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0002605 dipeptide repeat protein toxicity suppressed Normally toxic dipeptide repeat proteins appear to be less toxic to animals, compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00059748

0 Strain