WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00106742 Genotype  pgp-12::GFP
Phenotype Remark  "Specifically, we injected the dsRNA derived from each gene into the worm expressing a chromosomally integrated marker, that is, pgp-12::GFP, which is exclusively expressed in the excretory cell post-embryonically (Zhao et al, 2005). Examining the morphological defects in excretory canals revealed that all of the surviving L1 larvae showed various defects in the excretory canals (Supplementary Fig S9I-P). RNAi against snfc-5 also produced an extra nucleus, suggesting a defect in fate specification of the excretory cell. RNAi against tbx-33 and ceh-43 produced canals with a 'thorn'-like protrusion. Inactivation of let-526 and arx-1 led to incomplete canals while that of sptf-3 seemed to affect tube morphogenesis. RNAi against most of these genes (i.e sptf-3) induced a high penetrance of embryonic lethality. Therefore, the morphological changes in the excretory canal should be treated as a hypomorphic rather than a null phenotype." Remark  (Figure S9) let-526 RNAi
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00002717 let-526 C01G8.9 Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:C01G8.9a C01G8.9a 5064   I: 5301768-5301905
CDS:C01G8.9d C01G8.9d 5226   I: 5301768-5301905
CDS:C01G8.9c C01G8.9c 5307   I: 5301768-5301905

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000704 excretory canal morphology variant Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00046953

0 Strain