WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00087532 Phenotype Remark  Disrupting par-2 or par-3 function in combination with Galpha had effects on microtubule stability that suggest that PAR proteins affect microtubules independently of G protein signaling: the difference in microtubule stability at the cortex between Galpha(RNAi); par-2(RNAi) and Galpha(RNAi); par-3(RNAi) was on average 15%, similar to the difference in microtubule stability found between embryos where the function of par-2 and par-3 was disrupted individually (p < 0.05). Taken together, these results indicate that Galpha and PAR-3 regulate microtubule dynamics at the cortex, in manners that are at least partially independent.
Remark  paper remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

3 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001648 goa-1 C26C6.2 Caenorhabditis elegans
WBGene00001678 gpa-16 Y95B8A.5 Caenorhabditis elegans
WBGene00003917 par-2 F58B6.3 Caenorhabditis elegans

9 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y95B8A.5c Y95B8A.5c 348   I: 904617-904844
CDS:F58B6.3a F58B6.3a 1887   III: 1081409-1081519
CDS:F58B6.3b F58B6.3b 1749   III: 1081409-1081519
CDS:F58B6.3c F58B6.3c 228   III: 1094240-1094374
CDS:C26C6.2 C26C6.2 1065   I: 7522210-7522370
CDS:F58B6.3d F58B6.3d 1746   III: 1081409-1081519
CDS:F58B6.3e F58B6.3e 486   III: 1091647-1091697
CDS:Y95B8A.5a Y95B8A.5a 1074   I: 897290-897355
CDS:Y95B8A.5b Y95B8A.5b 381   I: 903485-903511

1 Laboratories

Primary Identifier
LP

1 Phenotype

Identifier Name Description
WBPhenotype:0001588 microtubule organization biogenesis variant Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00005827

0 Strain