WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00087528 Phenotype Remark  Disrupting the function of par-2 or par-3 resulted in changes in microtubule dynamics at the cortex. In both backgrounds, anterior and posterior microtubules had equal residence time at the cortex. This indicates that PAR-2 and PAR-3 are required for the asymmetric regulation of microtubule dynamics at the cortex in C. elegans embryos. Furthermore, the residence time at the cortex of microtubules in par-2(RNAi) embryos was on average 14% longer than in par-3(RNAi) embryos, which suggests that PAR-2 and PAR-3 proteins have opposite effects on microtubule stability.
Remark  paper remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003917 par-2 F58B6.3 Caenorhabditis elegans

5 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F58B6.3a F58B6.3a 1887   III: 1081409-1081519
CDS:F58B6.3b F58B6.3b 1749   III: 1081409-1081519
CDS:F58B6.3c F58B6.3c 228   III: 1094240-1094374
CDS:F58B6.3d F58B6.3d 1746   III: 1081409-1081519
CDS:F58B6.3e F58B6.3e 486   III: 1091647-1091697

1 Laboratories

Primary Identifier
LP

1 Phenotype

Identifier Name Description
WBPhenotype:0001588 microtubule organization biogenesis variant Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00005827

0 Strain