WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00106285 Genotype  unc-45(e286)
Phenotype Remark  "To re-examine the role of these co-chaperones in muscle function, wild-type and unc-45(e286) animals were treated with RNAi for known Hsp90 co-chaperones (Haslbeck et al., 2012, 2013) (17 genes; Table 1) and changes in motility were monitored. The detection threshold was increased in this secondary screen and animals were scored for any change in motility. Of the genes examined, only down-regulation of C-elegans p23 (Cep23; ZC395.10) resulted in motility defects of unc-45(e286) mutant animals but not wild-type animals. 39 11.3% of the unc-45(e286) mutant animals examined were motile (Figures 4A,B and data not shown). Although Cep23 modulated unc-45(ts) motility to a lesser extent than CeHop or CeAha1 (Figures 2C, 4B), Cep23 effect on unc-45(ts) motility was highly significant (p < 0.005)." Remark  (Figure 4) ZC395.10/Cep23 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation. If Ahringer clone not available, Vidal laboratory clone used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00022599 daf-41 ZC395.10 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:ZC395.10 ZC395.10 528   III: 5273989-5274047

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000644 paralyzed Animals do not move and are not responsive to external mechanical stimulation.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00046852

0 Strain