WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00101916 Genotype  L-AChR(gf) (ufIs6)
Phenotype Remark  This RNAi was able to suppress the locomotion phenotypes found in L-AChR(gf) animals. L-AChR(gf) enhances synaptic activation of muscles by increasing L-AChR function. Remark  The authors wanted to enhance synaptic activation of muscles by increasing L-AChR function, thus they introduced an amino acid change at a highly conserved position in the pore-lining M2 regions of cDNAs encoding the UNC-29, UNC-38 and LEV-1 subunits. They constructed a strain (ufIs6) stably expressing the unc-29(L/S), unc-38(V/S) and lev-1(L/S) cDNAs under control of the muscle-specific myo-3 promoter, and refer to this as L-AChR(gf).
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003753 nlp-15 CC4.2 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:CC4.2 CC4.2 432   I: 12988275-12988334

1 Laboratories

Primary Identifier
IZ

1 Phenotype

Identifier Name Description
WBPhenotype:0000643 locomotion variant Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00045671

0 Strain