WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00107699 Phenotype Remark  "During AC invasion, the c-fos transcription factor ortholog fos-1 promotes expression the zinc metalloprotease zmp-1, the protocadherin cdh-3, the zinc finger protein egl-43, the hemicentin extracellular matrix protein gene him-4, and lamillopodin/mig-10; the activities of these genes induce the AC to form ventrally directed protrusions that breach the basement membrane (Fig 6A; Sherwood et_al, 2005; Hwang et_al 2007; Wang et_al, 2014). RNAi against the AC invasion genes resulted in defects in utse development (Table 2E; Fig 6B-D; F-H; J-L; N-P; R-T; V-X), supporting our hypothesis that genes involved in AC protrusion formation also affect utse development... The majority of fos-1(RNAi) and egl-43(RNAi) treated worms did not form π or υ cells (Table 2E) but those shown in Fig 6 and Table 2E were animals in which π and subsequently υ cell induction occurred."
Remark  (Table 2, Figure 6) egl-43 RNAi
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001207 egl-43 R53.3 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:R53.3a R53.3a 1632   II: 9955186-9955305
CDS:R53.3b R53.3b 969   II: 9960333-9960485

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000529 cell development variant Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00045833

0 Strain