WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00110387 Phenotype Remark  "An anti-chondroitin sulfate antibody has been previously used to detect the presence of chondroitin (one of the secreted GAGs) on the cell surface of embryonic cells and gonad (Mizuguchi et al. 2003). Using this antibody, we observed the reported staining for wild-type embryos (Fig. 3P,Q) but did not detect the antigen on the acs-1(RNAi)C17ISO embryo cell surface (Fig. 3R,S). Biosynthesis of chondroitin was not disrupted in the acs-1(RNAi)C17ISO animals, as it was readily detectable in the gonads (Fig. 3T,U). These data suggested that the absence of the perivitelline space in acs-1(RNAi)C17ISO embryos may have been caused, at least in part, by defective exocytosis of GAGs."
Remark  (Figure 3R, 3S) acs-1(RNAi)
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00018488 acs-1 F46E10.1 Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F46E10.1b F46E10.1b 1794   V: 6527511-6527520
CDS:F46E10.1c F46E10.1c 1737   V: 6529269-6529439
CDS:F46E10.1a F46E10.1a 1872   V: 6525095-6525136

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000425 antibody staining reduced Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00040893

0 Strain