WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00082038 Phenotype Remark  Disorganization of HCP-3 (centromeric protein) loading onto chromosomes. Instead of poleward localization on both sides of the metaphase plate, HCP-3 was distributed over the metaphase chromosomes in an interrupted pattern that extended throughout the spindle midzone. Another centromeric protein, HCP-4/CENP-C showed the same disorganization. In addition the outer kinetochore protein KLP-7/MCAK (a kinesin) and the conserved spindle checkpoint protein BUB-1 were loaded in a similar disorganized manner.
Remark  Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001214 ego-1 F26A3.3 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F26A3.3 F26A3.3 4899   I: 7650667-7650833

1 Laboratories

Primary Identifier
WM

2 Phenotype

Identifier Name Description
WBPhenotype:0000436 protein subcellular localization variant Any variation in the placement of a protein within in a cell or cellular compartment compared to control.
WBPhenotype:0001910 kinetochore organization variant Animals exhibit variations in the assembly, arrangement, orientation, or disassembly of the kinetochore, a multisubunit protein complex on chromosomes where the spindle fibers attach during cell division to pull the chromosomes apart.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00035270

1 Strain

WormBase ID
WBStrain00000001