WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00103054 Genotype  unc-119(ed4)III; hhIs64 [unc-119(?); sur-5::UbV-GFP]III (strain listed as PP563).
Phenotype Remark  Knockdown of oxi-1 by RNAi only minimally affected the degradation of UbV-GFP under basal conditions. However exposing worms to low doses of the oxidative stress-inducing agent paraquat resulted in stabilization of UbV-GFP (loss of degradation). Remark  Authors engineered a ubiquitin fusion degradation(UFD) substrate in which a noncleavable ubiquitin is N-terminally fused to GFP (UbV-GFP) and expressed under the control of the sur-5 promoter to monitor protein degradation in vivo.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003898 oxi-1 Y39A1C.2 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y39A1C.2 Y39A1C.2 3201   III: 10858313-10858458

0 Laboratories

2 Phenotype

Identifier Name Description
WBPhenotype:0001645 protein degradation variant Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control.
WBPhenotype:0000460 paraquat response variant Animals exhibit variations in their response to paraquat compared to that observed in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00041777

0 Strain