WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00107820 Phenotype Remark  Figure 3, unsealed phagosomes can be labeled by PLCδ1-PH and the membrane impermeable dye FM4-64. Loss of mtm-1, piki-1, lst-4, dyn-1 or ocrl-1 shows phagosome sealing defective. "Inactivation of OCRL-1 causes persistent cell corpses, which are labeled by FM4-64, Annexin V, and PLCδ1-PH, indicating that PtdIns(4,5)P2 hydrolysis is required for sealing of apoptotic cell-containing phagosomes (Fig 2, P-Q'; Fig 3, G-G'', L, and M; and Fig S3, E-E''', H, and I). Consistent with the sealing defect, ocrl-1(lf) phagosomes were not acidified, and the recruitment of maturation factors (RAB-5 and RAB-7) and lysosomes (NUC-1) was blocked (Fig 2, R-U' and X)."
Remark  ocrl-1 RNAi
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00007620 ocrl-1 C16C2.3 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:C16C2.3a C16C2.3a 2139   I: 9715633-9715757
CDS:C16C2.3b C16C2.3b 816   I: 9715633-9715757

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0002394 phagosome sealing defective The closure of a phagosome does not occur and it remains connected with the plasma membrane, leaving the lumen open to the outside. Complete closure usually occurs once an apoptotic cell has been surrounded by an engulfing cell.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00048406

0 Strain