1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00002977 | lev-10 | Y105E8A.7 | Caenorhabditis elegans |
| Primary Identifier | Expr3455 | Remark | LEV-10A or LEV-10B were expressed under the control of the muscle-specific promoter myo-3 in lev-10(kr26) animals. Both proteins rescued behavioural defects and UNC-29 synaptic clustering when expressed in muscle. Genetic mosaic analysis confirmed that LEV-10 is required cell autonomously in postsynaptic muscle cells for AChR clustering at NMJs. |
| Subcellular Localization | In wild-type animals, LEV-10 is concentrated at cholinergic NMJs. Double labelling experiments with an antibody against the vesicular acetylcholine transporter UNC-17 demonstrated that 93 plusminus 3% of LEV-10 puncta were associated with cholinergic varicosities (mean plusminus SEM, 104 puncta counted in seven worms). However, three-dimensional analysis of confocal image stacks revealed that LEV-10 staining was juxtaposed to, but did not overlap, UNC-17 distribution. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00002977 | lev-10 | Y105E8A.7 | Caenorhabditis elegans |
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