| Pattern | SUP-46 is present in the nucleus, cytoplasm, and multiple RNA granules.SUP-46 was expressed ubiquitously in germline and somatic cells. In the germline, SUP-46 was cytoplasmic in mitotic cells in the distal region, and nuclear in the non-dividing cells of the distal, transition, and meiotic zones. Within germ nuclei, SUP-46 was present diffusely, and in granules associated with active chromatin, marked by H3K4me2, but not the inactive X chromosome marked by H3K9me2. Just before ovulation, SUP-46 exited the nucleus and accumulated in the cytoplasm of the meiotic '-1' oocyte (position relative to spermatheca). Similarly, during spermatogenesis SUP-46 was nuclear and chromatin associated during spermatogenesis, but then accumulated in the sperm anucleate meiotic residual body, which captures spermatocyte cytoplasm following completion of meiosis. During oogenesis in the diakinesis region, in addition to localizing to chromatin, SUP-46 also accumulated in the nucleolus (until nucleolar breakdown in the '-2' to '-1' oocyte). In the embryo, SUP-46 was primarily nuclear in non-dividing cells and cytoplasmic in dividing cells. In P1 and P2, which ultimately give rise to the germline during larval development, SUP-46 also accumulated in cytoplasmic granules that were reminiscent of P (germ) granules. Immunolocalization of the constitutive P granule protein PGL-1 confirmed that SUP-46 is present in P granules in the embryo, but not in the adult (gonad). | Primary Identifier | Expr15106 |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Nucleated cell which has a diploid set of chromosomes. | somatic cell | FMA:72300 | WBbt:0008378 |
| a cell, of either sex, directly concerned in the production of a new organism. | germ cell | WBbt:0006796 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00045383 | sup-46 | C25A1.4 | Caenorhabditis elegans |
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