| Pattern | At the time of invasion GFP::UNC-60A was present throughout the uterine tissue and at elevated levels in the anchor cell (1.35-fold greater levels versus neighboring uterine cells; n = 11 animals examined). GFP::UNC-60A was also more enriched at the invasive cell membrane (1.29-fold enrichment vs. 0.75-fold for neighboring uterine cells; n = 11 animals examined). | Primary Identifier | Expr11655 |
| Subcellular Localization | GFP::UNC-60A localized in punctate structures at the AC-basement membrane interface before invasion. To determine whether these structures were invadopodia, their localization was examined relative to F-actin and basement membrane breaching. A tight correlation between F-actin localization and UNC-60A enrichment at the AC-basement membrane interface was observed, as well as localization to the invadopodium that breached the basement membrane. Further, UNC-60A localization to the AC-basement membrane interface was dependent on the integrin INA-1/PAT-3, whose activity is required for invasion and promotes the localization of other invadopodia constituents. Thus, UNC-60A is a component of AC invadopodia. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| The organ in which the eggs are developed and protected until laid. | uterus | WBbt:0006760 | |
| anchor cell, induces vulva, part of hermaphrodite gonad. | anchor cell | AC | WBbt:0004522 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00006794 | unc-60 | C38C3.5 | Caenorhabditis elegans |
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