| Pattern | SKN-1 immunoreactivity is observed in all dopaminergic (DA) neurons. | Primary Identifier | Expr9129 |
| Remark | No specific staining was observed in primary DA neurons or other cells from animals in which skn-1 mRNA levels were reduced using RNAi. Furthermore, SKN-1-associated DA neuron immunoreactivity was not observed following co-incubation of the cultures with the SKN-1 antibody and the complementary antigenic peptide, providing further proof that the antibody is binding to the SKN-1 protein in the DA neurons. Taken together, these results indicate that SKN-1 is expressed in DA neurons, and that a reduction in the transcription factor mRNA levels by RNAi results in a significant loss of SKN-1 immunoreactive protein expression in the DAergic cells. Picture: Fig 5, Fig S2. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Neuron that uses dopamine (DA) as a neurotransmitter. | dopaminergic neuron | WBbt:0006746 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004804 | skn-1 | T19E7.2 | Caenorhabditis elegans |
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