1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00014177 | frg-1 | ZK1010.3 | Caenorhabditis elegans |
| Primary Identifier | Expr9003 | Remark | Picture: Fig 3, Fig 4, Fig S2. |
| Subcellular Localization | Both FRG-1 and PAT-3 immunostaining produced identical but only partially overlapping and generally adjacent punctate patterns, indicating that FRG-1 is a component of all of the body-wall muscle dense bodies. Using confocal microscopy and focusing on only the dense bodies positioned at the edge of the organism allowed visualization of proteins positioned along the dense-body structure as it protruded into the muscle cytoplasm. Clearly, FRG-1 does not overlap with PAT-3 at the base of the dense body; instead FRG-1 immunostaining appeared adjacent to PAT-3 along the cytoplasmic finger-like projection of the dense body, where actin thin filaments attach. During C. elegans embryogenesis, FRG-1 was in fact primarily nuclear; however, diffuse cytoplasmic staining was also evident. In body-wall muscle of larval-stage animals, cytoplasmic FRG-1 began to form foci and showed a surprisingly striated and punctate immunostaining suggestive of the dense body. Similarly, in adult animals, cytoplasmic FRG-1 immunostaining retained its striking dense-body-like pattern. Antibody characterization indicated that this cytoplasmic immunostaining represents FRG-1. FRG-1 localized in body-wall muscle nuclei in larva and adults, localized primarily to the DAPI-poor regions indicative of nucleoli. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00014177 | frg-1 | ZK1010.3 | Caenorhabditis elegans |
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