| Primary Identifier | Expr11675 | Subcellular Localization | In 2-cell to 32-cell embryos, CDC-42 mainly localized to cortexes at cell-cell contacts. At late stages of embryonic development, we also observed a widespread CDC-42 expression in neuronal tissues such as the nerve ring, supporting the involvement of CDC-42 in neuronal processes. During larval development and in adults, CDC-42 localized to cortexes in all cells, for example, in the vulva and in the tail. Previous work has shown that CED-1 and CED-6 in engulfing cells are selectively recruited to the plasma membrane surrounding apoptotic cells, generating a 'halo' pattern around the corpses. A similar accumulation of GFP::CDC-42 was observed around apoptotic cell corpses during all developmental stages. Importantly, CDC-42 was significantly enriched at membranes surrounding apoptotic cell corpses compared with cortical basal as well as background levels. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| female genital. | vulva | WBbt:0006748 | |
| the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes. | nerve ring | circumpharyngeal nerve ring | WBbt:0006749 |
| posterior region, from rectum to the end | tail | WBbt:0005741 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000390 | cdc-42 | R07G3.1 | Caenorhabditis elegans |
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