| Primary Identifier | Expr13138 | Subcellular Localization | GRDN-1a::GFP was broadly expressed during embryogenesis and was enriched at the presumptive nose starting at mid-embryogenesis, coinciding with the time period of sensory neuron differentiation and ciliogenesis (Sulston et al., 1983).The subcellular localization of GRDN-1a::GFP was reminiscent of that previously reported for BB and TZ proteins in embryonic head sensory neurons (e.g., Dammermann et al., 2009). Consistent with this notion, GRDN-1a::GFP was present at the AWB cilia base in larvae, and co-localized with the BB markers DYF-19 and GASR-8 in the PHA/PHB ciliated tail neurons in L1 larvae and adult AWB neurons, respectively. Intriguingly, GRDN-1a::GFP appeared to be enriched at the proximal ends of centrioles, and was completely excluded from the TZ marked by MKS-5::tagRFP. Together, these observations suggest that Girdin is localized to the BBs in C. elegans sensory neurons. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| neuron that senses external stimuli and transduce them to signals internal to the organism. | sensory neuron | WBbt:0005759 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00013082 | grdn-1 | Y51A2D.15 | Caenorhabditis elegans |
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