WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  NOS-3 protein detected throughout the germ-line tissue during larval development. In addition to staining in the larval gonad, NOS-3 expression was also observed in embryos. Specifically, NOS-3 was found in P1P4, and later in germ-line progenitor cells, Z2 and Z3. Primary Identifier  Expr1203
Remark  Staining with anti-NOS-3 antibodies was specific, in that it was dramatically reduced in nos-3 deletion mutants. Subcellular Localization  At all stages of germ-line development, NOS-3 was predominantly cytoplasmic: this was evidenced by the dark, non-staining `holes' corresponding to nuclei in the germ line at the larval L3 stage. The distribution of NOS-3 overlapped with regions of the cytoplasm containing P granules, detected using anti-PGL-1 antibodies; however, within the cytoplasm, NOS-3 staining was uniform and diffuse throughout. At the late L4 stage, NOS-3 was detected in germ cells in mitosis and meiotic pachytene, but decreased in the spermatogenic region. Although the distribution of NOS-3 in P cells was punctate, it did not precisely coincide with P granules.
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7 Anatomy Terms

Definition Name Synonym Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes. germ line germline WBbt:0005784
embryonic founder cell Psub3 lineage name: P0.ppp WBbt:0006875
embryonic founder cell Psub1 lineage name: P0.p WBbt:0006874
embryonic founder cell Psub2 lineage name: P0.pp WBbt:0006873
Embryonic founder cell of germ line Psub4 lineage name: P0.pppp WBbt:0004421
Germ line precursor cell Z3 lineage name: P4.a WBbt:0004575
Germ line precursor cell Z2 lineage name: P4.p WBbt:0004576

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003785 nos-3 Y53C12B.3 Caenorhabditis elegans

2 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003
  A developmental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until adulthood. larva Ce WBls:0000023