WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

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Expression Pattern :

Pattern	In adults, CDT-1 is present in germ cell nuclei and is enriched in oocyte nuclei. In early embryos, CDT-1 is localized to chromosomes in mitotic cells during anaphase and early telophase. CDT-1 nuclear staining is not present in S phase, which directly follows mitosis in the early embryo. Anti-CDT-1 staining in embryos is abolished by cdt-1 RNAi, indicating the validity of the staining pattern. Newly hatched larvae lack detectable CDT-1 expression. However, CDT-1 levels are transiently increased in the nuclei of blast cells before their mitotic divisions. In the wild type, CDT-1 expression began approximately 20 min after hatching in a subset of seam cells, and by 120 min post-hatch all seam cells expressed CDT-1 at high levels. At 130 min post-hatch, the number of seam cells with CDT-1 protein dropped precipitously, and by 150 min post-hatch most seam cells no longer had CDT-1 protein. Significantly, the decrease in CDT-1 levels in S-phase cells occurred in both the nucleus and cytoplasm, indicating that CDT-1 does not undergo subcellular redistribution, but instead is degraded.	Primary Identifier	Expr2561
Subcellular Localization	nuclei

1 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000413	cdt-1	Y54E10A.15	Caenorhabditis elegans

2 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003

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