| Pattern | The LIN-23 protein is present both in all blast cells of embryos and in the wild-type germline. LIN-23 is present in the germline from the tip of the distal arm to the maturing oocytes. Its abundance seems relatively similar between the distal and proximal zones; however, its localization is concentrated within cytosol and is relatively excluded from nuclei. The distal region of the gonad is a syncytial tube with the germline nuclei packed around the outside with a hollow core. We find that LIN-23 is concentrated throughout the core and in the cytosolic spaces between the nuclei and is either absent from, or present at a much reduced level, in the nuclei themselves. Within developing oocytes in the proximal region of the gonad, it is also more abundant in the cytoplasm than nuclei. An interesting observation was the differential localization of LIN-23 in the cells of the early embryo. It is generally distributed throughout the cytosol, but its localization is dynamic being differentially excluded from the nucleus for much of the cell cycle, but a fraction of it accumulates to the nuclear compartment late in the cycle shortly before cell division. In the embryos shown, the nuclear compartment accumulation of LIN-23 is seen in a late AB blastomere but is absent in a slightly younger AB blastomere. Similarly, it can be seen in both the ABa and ABp blastomeres but absent from the nuclei of the EMS and P2 blastomeres. Because the ABa and ABp blastomeres divide slightly earlier than EMS and P2, they are inevitably later in the cell cycle. However, this pattern is not lineage dependent. | Primary Identifier | Expr12833 |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes. | germ line | germline | WBbt:0005784 |
| precursor cell destined to divide some time after hatching. | blast cell | WBbt:0006783 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003009 | lin-23 | K10B2.1 | Caenorhabditis elegans |
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