WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  Whole mount antibody staining established the expression of the protein at the baso-lateral membranes of gut epithelia in embryonic and post-embryonic stages. Its expression was restricted to gut and was not observed in other polarized epithelia, such as the pharynx or post-embryonic vulva, uterus, and hypodermis. Immunoelectron microscopy experiments confirmed localization of ITX-1 to intestinal adherens junctions. Primary Identifier  Expr9162
Remark  Picture: Fig. 5A to 5C. Subcellular Localization  ITX-1 defines a lateral membrane domain basal to the apical junction. However, ITX-1 staining along the apical junction appears as a wider belt differently than the typical AJM/DLG pattern. Moreover, ITX-1 localization is independent of AJM-1, as ajm-1 null mutant embryos show normal ITX-1 staining. Co-labeling of ITX-1 with anti beta-G Spectrin show that it co-localizes with ITX-1 along the entire lateral membrane of gut epithelia.
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1 Anatomy Terms

Definition Name Synonym Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages. intestine gut WBbt:0005772

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00002174 itx-1 W03D8.6 Caenorhabditis elegans

6 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003