WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  The cog-2::gfp transcriptional fusion is expressed in a similar pattern to the translational fusion in the pi and pi lineages. The expression pattern of the transcriptional fusion differs from the translational fusion in that the body wall muscles express the fusion protein at a higher level than any other cell and fewer neurons expressing cog-2::gfp can be detected with the transcriptional fusion, although the same brightly expressing cells that stand out with the translational fusion are visible. Translational construct: cog-2::gfp is expressed in a dynamic pattern in cells of the pi-lineage. No expression is visible in the gonad until the pi cell precursors are born. At this point, expression is evident in all pi cell precursors as well as in the single pi precursor on each side that has a pi cell precursor as a sister. After the pi cell precursors undergo their single and final division, cog-2::gfp expression is still bright in the pi cells, but expression is usually no longer evident in the lineage. Most animals show no expression of COG-2::GFP expression past the precursor stage in the pi lineage, although in a few animals, faint GFP expression was observed in the daughters, but never the granddaughters, of the expressing pi precursor. cog-2::gfp expression remains strong in the lineage throughout the L4 stage, becoming slightly brighter in the pi cells that adopt the uv1 fate. In addition, the AC nucleus begins to express cog-2::gfp after fusion with the utse cell. Expression in the AC is not detectable before the time of fusion. cog-2::gfp expression is not detectable in the vulva at any stage, in any other part of the gonad including the distal tip cells, or in the hypodermis. cog-2::gfp is expressed in most, if not all, neurons in the head and the tail of the animal. However, four unidentified cells in the head express cog-2::gfp at a higher level than others. Expression is also faintly visible in the body wall muscles and the intestinal cells. Primary Identifier  Expr1295
Subcellular Localization  Translational construct: COG-2::GFP is a nuclear protein.
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4 Anatomy Terms

Definition Name Synonym Primary Identifier
neuron with its cell body situated in the head, excluding the pharynx. head neuron   WBbt:0006751
neuron with its cell body situated in the tail, posterior to rectum. tail neuron   WBbt:0006759
membranous cell attaches the uterus to the lateral epidermis (seam) and forms a thin laminar process dorsal to the vulva. formed by fusion of eight pi cell progeny and AC. uterine seam cell utse WBbt:0006789
any of 20 large epithelial cells which form a tube and are mostly situated as bilaterally symmetric pairs around the tubular lumen. Each of these cell pairs forms an intestinal ring ( II-IX int rings). The most anterior intestinal ring (int ring I), however, is made of four cells. Intestinal cells contain large nuclei with large nucleoli and numerous autofluorescent granules in their cytoplasm. intestinal cell   WBbt:0005792

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001182 egl-13 T22B7.1 Caenorhabditis elegans

1 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038