WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  C. elegans whole-mount staining with TBH-1 antibodies labeled a single pair of head interneurons in the lateral ganglion: these neurons were identified as the RICs. Punctate TBH-1 staining was also observed in the gonadal sheath cells of adult hermaphrodites. TBH-1 staining was most prominent in the proximal three pairs of sheath cells, which form a contractile myoepithelium that expels oocytes from the gonad during ovulation. Primary Identifier  Expr3721
Remark  No staining was observed in tbh-1(n3247) mutants. Subcellular Localization  Bright staining was observed in RIC synaptic regions, as indicated by a punctate immunofluorescence pattern in the nerve ring, whereas weaker staining was observed in the RIC neuronal processes and cell bodies. By contrast, TBH-1 staining was predominantly localized to the RIC cell bodies of mutants defective in the unc-104 gene, which encodes a neuron-specific kinesin required for the anterograde transport of synaptic vesicles. TBH-1, like the closely related dopamine B-hydroxylase, probably is associated with synaptic vesicles.
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3 Anatomy Terms

Definition Name Synonym Primary Identifier
Ring interneuron RICL lineage name: ABplppaaaapp WBbt:0003941
Ring interneuron RICR lineage name: ABprppaaaapp WBbt:0003940
five pairs of thin gonadal sheath cells form a single layer covering the germ line component of each arm, each pair occupying a stereotyped position along the gonad proximal-distal axis. gonadal sheath cell   WBbt:0005828

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00006541 tbh-1 H13N06.6 Caenorhabditis elegans

0 Life Stages