WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  Consistent with single-cell RNA sequencing data and previous reporter analyses, we found that gpla-1 is predominantly expressed in neurons associated with the gastrointestinal tract, which are part of the enteric nervous system in C. elegans. These include the pharyngeal neurons M1, M5, I5 and NSM, as well as the excitatory motor neurons AVL and DVB that control enteric muscle contractions in the hindgut during defecation. We also observed expression of gplb-1 in the enteric DVB neuron. In addition, both gpla-1 and gplb-1 reporter transgenes show fluorescence in the RME motor neurons that innervate the head muscles. Using a reporter transgene for GABAergic neurons, we confirmed that gpla-1 and gplb-1 are both expressed in the GABAergic DVB and RME neurons. In addition, the gplb-1 reporter transgene shows expression in non-neuronal tissues, including the head mesodermal cell (hmc) and the enteric muscles of the hindgut, which are involved in defecation. Taken together, these results indicate that expression of gpla-1 and gplb-1 co-localizes in the RME neurons in the head and the enteric neuron DVB in the tail, whereas no overlapping expression is seen in the pharyngeal neurons (gpla-1) or hmc and the enteric muscles (gplb-1). Primary Identifier  Expr16470
Paste the following link
Lists
This ExpressionPattern isn't in any lists. Upload a list.

11 Anatomy Terms

Definition Name Synonym Primary Identifier
Neuron class of one pharyngeal motorneuron. M5 neuron lineage name: MSpaaapap WBbt:0004465
Neuron class of one pharyngeal interneuron, posterior sensory. I5 neuron I5 WBbt:0004740
Pharyngeal neurosecretory motorneuron, contain serotonin NSML lineage name: ABaraapapaav WBbt:0004457
Pharyngeal neurosecretory motorneuron, contain serotonin NSMR lineage name: ABaraapppaav WBbt:0004446
Ring motor neuron RMER lineage name: ABalaaaarrp WBbt:0005023
Ring motor neuron RMED lineage name: ABalapppaap WBbt:0005027
Ring motor neuron RMEV lineage name: ABplpappaaa WBbt:0005021
Ring motor neuron RMEL lineage name: ABalaaaarlp WBbt:0005025
Neuron class of one ring interneuron, cell body in dorsorectal ganglion, inervates rectal muscles. DVB lineage name: K.p WBbt:0004822
Neuron class of one ring and ventral cord interneuron, few synapses. AVL lineage name: ABprpappaap WBbt:0003843
Neuron class of one pharyngeal motorneuron. M1 neuron lineage name: MSpaapaaa WBbt:0004488

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001466 gpla-1 F58H1.4 Caenorhabditis elegans

0 Life Stages