WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  Only antibodies raised to a region shared by all VAB-8 isoforms detected endogenous protein in whole mounts. In both embryos and larvae, endogenous VAB-8 were detected in each body wall muscle cell but not in any other cells. Muscle cells express VAB-8S. VAB-8L is absent in muscle cells as muscle staining is not observed in animals containing a VAB-8L tagged transgene. VAB-8S localization in muscle cells is punctate. Each muscle cell localizes VAB-8S to its anterior end starting late in embryogenesis. VAB-8L was expressed in AVKR, and VAB-8S was expressed in the CANs. Other cells expressing VAB-8 included motorneurons in the ventral nerve cord that extend posteriorly directed processes(DBs and DDs), interneurons that extend posteriorly directed axons in the dorsal lateral and ventral lateral nerve bundles (SI and SM classes), and additional unidentified neurons in the pharynx and head. VAB-8 was also expressed in body wall muscle. Primary Identifier  Expr1433
Subcellular Localization  By antibody staining: VAB-8S is punctate and roughly colocalizes with thin filaments in preparations double-stained with phalloidin to detect actin. Punctate muscle staining is reminiscent of dense bodies, structures that attach actin thinfilaments to the extracellular matrix. Although not in dense bodies, VAB-8S is near these structures. VAB-8 was expressed in body wall muscle. In expressing cells, GFP was distributed intracellularly, being excluded from the nucleus.
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24 Anatomy Terms

Definition Name Synonym Primary Identifier
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion. body wall musculature body muscle WBbt:0005813
neuron with its cell body situated in the head, excluding the pharynx. head neuron   WBbt:0006751
Neuron class of six motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. Each cell has a short, posteriorly directed and a longer, anteriorly directed process emanating from its cell body. The anterior process has a branch, which leaves the ventral cord as a commissure and runs round to the dorsal cord. DD neuron   WBbt:0005270
Neuron class of seven motoneurons that innervate dorsal muscles and have cell bodies in the ventral cord. DB neuron   WBbt:0005274
neuron of the pharyngeal nervous system. pharyngeal neuron   WBbt:0005439
Process runs along excretory canal, no synapses, essential for survival CANL lineage name: ABalapaaapa WBbt:0004949
Process runs along excretory canal, no synapses, essential for survival CANR lineage name: ABalappappa WBbt:0004947
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMDVR lineage name: ABarappppaa WBbt:0004969
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMDDR lineage name: ABprpapaaaa WBbt:0004971
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMDVL lineage name: ABalppappaa WBbt:0004970
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBVR lineage name: ABprpapaapp WBbt:0004977
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMDDL lineage name: ABplpapaaaa WBbt:0004972
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBDL lineage name: ABplppaaaaa WBbt:0004981
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBDR lineage name: ABprppaaaaa WBbt:0004979
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIBVL lineage name: ABplpapaapp WBbt:0004978
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBVR lineage name: ABarappappp WBbt:0004973
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBDL lineage name: ABalpapapapp WBbt:0004976
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBDR lineage name: ABarappapapp WBbt:0004975
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally SMBVL lineage name: ABalpapappp WBbt:0004974
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIAVL lineage name: ABplpapappa WBbt:0004985
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIAVR lineage name: ABprpapappa WBbt:0004983
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIADR lineage name: ABprpapaapa WBbt:0004987
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally SIADL lineage name: ABplpapaapa WBbt:0004989
Ring and ventral cord interneuron. AVKR lineage name: ABprpapapap WBbt:0003844

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00006874 vab-8 K12F2.2 Caenorhabditis elegans

2 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003
  A developmental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until adulthood. larva Ce WBls:0000023