WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  The immunoreactivity of OCR-2::FLAG and OCR-2(G36E)::FLAG is detected in the cilia and plasma membrane of the chemosensory neurons ADF, AWA, ASH, and ADL. Primary Identifier  Expr3165
Remark  Whereas ocr-2(ak47) animals carrying the OCR-2::FLAG transgene restore tph-1 expression (68% show strong tph-1::gfp in ADF; n = 79), ocr-2(ak47) animals that carry OCR-2(G36E)::FLAG (n = 79) exhibit reduced tph-1::gfp expression as their nontransgenic siblings (n = 235). These data indicate that FLAG-tagged OCR-2 is localized to the cellular sites in which OCR-2 acts and that the G36E substitution does not alter the subcellular localization. These results suggest that the G36E substitution disrupts the function of the OCR-2/OSM-9 channel in the ADF neurons. Subcellular Localization  Expressed in cilia and plasma membrane of the chemosensory neurons ADF, AWA, ASH, and ADL.
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8 Anatomy Terms

Definition Name Synonym Primary Identifier
Amphid neuron, prob. chemosensory ADFL lineage name: ABalpppppaa WBbt:0004003
Amphid neuron, prob. chemosensory ADFR lineage name: ABpraaappaa WBbt:0003999
Amphid neuron, prob. chemosensory ADLL lineage name: ABalppppaad WBbt:0003997
Amphid neuron, prob. chemosensory ADLR lineage name: ABpraaapaad WBbt:0003995
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASHL lineage name: ABplpaappaa WBbt:0003890
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASHR lineage name: ABprpaappaa WBbt:0003889
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWAL lineage name: ABplaapapaa WBbt:0003831
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWAR lineage name: ABpraapapaa WBbt:0003830

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003839 ocr-2 T09A12.3 Caenorhabditis elegans

0 Life Stages