WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  To examine lim-4 expression during the embryogenesis, the eggs were stained at various developing stages with anti-myc antibodies. A GFP reporter was used for the GATA gene elt-2, which is specifically expressed in the gut lineage, to stage the embryos. MYC::LIM-4 immunoreactivity is first detected in two cells approximately 160 min post-fertilization at 8 gut nuclei stage. The two MYC::LIM-4-staining cells was identified as the neuroblasts ABalpppppa and ABpraaappa that respectively give rise to left/right ADF and AWB neurons, based on triple labeling of the embryos with antibodies raised against the LIN-26 protein, which is expressed in the nuclei of the hypodermal cells that border the ADF/AWB mother cells. Like lim-4::gfp, the MYC::LIM-4 immunoreactivity is not detected in ADF at any stage of larvae or adults, but it is observed in AWB and several other neurons in the head throughout life (N > 200). It is difficult to determine if LIM-4 is excluded from ADF or it is present there transiently. Primary Identifier  Expr3765
Remark  This myc::lim-4 transgene potently rescues ADF serotonergic phenotype in yz12 mutants, indicating that the MYC::LIM-4 protein is expressed in cells necessary to specify ADF serotonergic identity.
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4 Anatomy Terms

Definition Name Synonym Primary Identifier
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWBL lineage name: ABalpppppap WBbt:0003829
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWBR lineage name: ABpraaappap WBbt:0003828
embryonic cell ABpraaappa   WBbt:0006483
embryonic cell ABalpppppa   WBbt:0006638

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00002987 lim-4 ZC64.4 Caenorhabditis elegans

0 Life Stages