WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  This reporter revealed a striking dimorphism across all stages: while hermaphrodite expression is low and restricted, males exhibit higher and broader neuronal GFP expression throughout development. We used "NeuroPAL" (Neuronal Polychromatic Atlas of Landmarks) to identify cell types using color barcodes. We found that in young adult hermaphrodites, INS-39 was specifically expressed in two sets of neurons, AFD and ASK. In contrast, in males, INS-39 was expressed in five sets of neurons, AFD, ASK, ASJ, ASE, and AWC, all of which are ciliated sensory neurons with thermosensory, chemosensory, olfactory, electrosensory, and photosensory functions. Using fluorescent dye staining of head ciliated sensory cells and an AFD marker, we validated the higher GFP intensity in ASK, ASJ, and AFD neurons in adult males compared to hermaphrodites. Taken together, the robust expression in sensory neurons in males from the earliest stages of development suggests INS-39 is under tight and sex-specific regulatory control. Primary Identifier  Expr16558
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11 Anatomy Terms

Definition Name Synonym Primary Identifier
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASEL lineage name: ABalppppppaa WBbt:0003904
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASER lineage name: ABpraaapppaa WBbt:0003903
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWCL lineage name: ABplpaaaaap WBbt:0003827
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWCR lineage name: ABprpaaaaap WBbt:0003826
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASKL lineage name: ABalpppapppa WBbt:0003884
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASKR lineage name: ABpraaaapppa WBbt:0003883
Amphid finger cell, neuron associated with amphid sheath AFDR lineage name: ABpraaaapav WBbt:0003991
Amphid finger cell, neuron associated with amphid sheath AFDL lineage name: ABalpppapav WBbt:0003993
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASJL lineage name: ABalpppppppa WBbt:0003886
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASJR lineage name: ABpraaappppa WBbt:0003885
Gonochoristic organism that can produce male gametes. male male organism WBbt:0007850

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00017668 ins-39 F21E9.4 Caenorhabditis elegans

0 Life Stages