WormMine

WSWS298

An integrated data resource for C. elegans and related nematodes

Expression Pattern :

Pattern  CDT-2::GFP is not detected in P cells at larval stage L1, but is expressed early in all Vulval Precursor Cells prior to their first division. The frequency of expression is lowest in P3.p cells, and highest in P6.p. After first division, the cells that adopted the vulval fate all express CDT-2::GFP, but the non-vulval cells generally do not. However, sometimes low expression can be observed in the descendants of P3.p, P4.p and P8.p. Interestingly, after second division (four-cell stage) CDT-2::GFP expression disappears from two secondary cells (P5.ppp and P7.paa); these are the only vulval cells that will not undergo a third cell division. Later, at L4 stage no expression is detected. CDT-2:GFP expression was also observed in the cytoplasm during the first mitotic division of P6.p, which quickly relocalised to the nuclei as the nuclear envelope reforms. The early CDT-2 pattern of expression is consistent with a role during vulval fate adoption, and its down regulation in cells that cease cell division is consistent with a role in DNA replication. Primary Identifier  Expr11577
Remark  Temporal description Subcellular Localization  The localisation of CDT-2 fused to GFP is predominantly nuclear in interphase and cytoplasmic during mitosis, which seems contrary with a function in endocytosis. However, the authors cannot exclude that a proportion of CDT-2::GFP below the limit of detection is cytoplasmic during interphase.
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2 Anatomy Terms

Definition Name Synonym Primary Identifier
cell that has the potential to form structural part of a vulva. vulval precursor cell VPC WBbt:0007809
Constituent cell of a hermaphrodite vulva. vulval cell vulval epithelial cell WBbt:0007831

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00011318 cdt-2 T01C3.1 Caenorhabditis elegans

1 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  A developmental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until adulthood. larva Ce WBls:0000023